Super-operatives Ecks and Sever both want their hands on a newly developed, micro-robotic assassination device. If they both survive their personal wars, the two foes are destined to become allies who take on the shadowy forces that are pitting them against each other.
In his latest mission, Machete is recruited by the U.S. President to stop a crazed global terrorist who is planning to start a nuclear war. Meanwhile, Machete has a bounty on his head, and he faces death from a series of deadly assassins.